Thomas C. Resta, PhD

Photo: Thomas RestaProfessor  


Research Interests 

  • Mechanisms of chronic hypoxia- and intermittent hypoxia-induced pulmonary hypertension 
  • Pulmonary vasoreactivity 
  • Endothelial regulation of vascular tone 
  • Regulation of vascular smooth muscle contraction by reactive oxygen species, nitric oxide, RhoA and PKC signaling 
  • Regulation of endothelial and vascular smooth muscle [Ca2+]i 

Education and Professional Positions actin

1990: B.S., Biology, University of New Mexico
1995: Ph.D., Physiology, University of New Mexico
1995-1998: Postdoctoral Fellow, Physiology, University of New Mexico
1998-2000: Research Assistant Professor, University of New Mexico
2000-2006: Assistant Professor, University of New Mexico
2006-2012: Associate Professor, University of New Mexico
2012-present: Professor, University of New Mexico


1998: Sidney Solomon Memorial Award for Excellence in Integrative Physiology, University of New Mexico
2000: Dean's Award of Distinction in Recognition of Outstanding Faculty Performance, University of New Mexico
2000-2003: Parker B. Francis Fellowship in Pulmonary Research, Harvard School of Public Health
2004-2005: Faculty Excellence in Teaching Award, Biomedical Sciences Graduate Program, University of New Mexico School of Medicine
2005: American Physiological Society Respiration Section New Investigator Award
2010-present: Fellow of the Pulmonary Vascular Research Institute
2010-2011: Faculty Excellence in Teaching Award, Phase I Medical Curriculum, UNM School of Medicine
2011: Elected Fellow of the American Heart Association

Professional Activities

2004-2007: Topic Editor, American Thoracic Society, Pulmonary Circulation Assembly On-Line Journal Club, Pulmonary Hypertension/Vascular Remodeling Section
2004-2008: Member, Editorial Board, Am. J. Physiol. Lung Cell. Mol. Physiol.
2004, 2008: Temporary Member, NIH-NHLBI Respiratory Integrative Biology and Translational Research (RIBT) Study Section
2007-2008: Regular Member, American Heart Association, Lung Resuscitation and Respiration, National Peer Review Committee
2007-2010: Member, American Heart Association, South Central Affiliate, Research Committee
2008-2010: Chairman, American Physiological Society, Respiration Section, Nominations Committee
2008-2012: Member, American Physiological Society, Respiration Section, Program Committee
2008-present: Member, American Physiological Society, Respiration Section, Steering Committee
2010-present: Member, American Physiological Society, Committee on Committees
2010-present: Member, Editorial Board, Pulmonary Circulation
2011-2013: Vice-Chairman, American Heart Association, Southwest Affiliate, Research Committee
2011-present: Member, Editorial Board, Am. J. Physiol. Heart Circ. Physiol.
2012-present: Regular Member, American Heart Association, Lung Respiration and Resuscitation – Basic Science 2, National Peer Review Committee
2013-present: Chairman, American Heart Association, Southwest Affiliate, Research Committee
2013-present: Member, American Heart Association, Southwest Affiliate, Board of Directors

Current Laboratory Personnel

Jessica Snow, Ph.D., Postdoctoral Fellow
Chuck Norton, Doctoral Student
Joshua Sheak, Doctoral Student
Levi Maston, Doctoral Student 
Minerva Murphy, Technician 

Selected Recent Publications

Jernigan NL and Resta TC.  Calcium homeostasis and sensitization in pulmonary arterial smooth muscle.  Microcirculation. 2013 Oct 1. doi: 10.1111/micc.12096. [Epub ahead of print].

Nitta CH, Osmond DA, Herbert LM, Beasley BF, Resta TC, Walker BR, Jernigan NL.  Role of ASIC1 in the development of chronic hypoxia-induced pulmonary hypertension.  Am J Physiol 306(1):H41-H52, 2014.

Norton CE, Broughton BRS, Jernigan NL, Walker BR, Resta TC.  Enhanced depolarization-induced pulmonary vasoconstriction following chronic hypoxia requires EGFR-dependent activation of NAD(P)H oxidase 2.  Antioxid Redox Signal.18(14):1777-1788, 2013.

Ramiro-Diaz JM, Nitta CH, Maston LD, Codianni S, Giermakowska W, Resta TC, Gonzalez Bosc LV.  NFAT is required for spontaneous pulmonary hypertension in superoxide dismutase 1 knockout mice.  Am J Physiol. 304(9):L613-L625, 2013.

Jernigan NL, Herbert LM, Walker BR, Resta TC.  Chronic hypoxia upregulates pulmonary arterial ASIC1: a novel mechanism of enhanced store-operated Ca2+ entry and receptor dependent vasoconstriction.  Am J Physiol 302(6):C931-C940, 2012.

Bierer R, Nitta C, Friedman J, Codianni S, de Frutos S, Dominguez-Bautista JA, Howard TA, Resta TC, Gonzalez Bosc LV. NFATc3 is required for chronic hypoxia-induced pulmonary hypertension in adult and neonatal mice. Am J Physiol 301(6):L872-L880, 2011.

Norton CE, Jernigan NL, Kanagy NL, Walker BR, Resta TC. Intermittent hypoxia augments pulmonary vascular smooth muscle reactivity to NO: regulation by reactive oxygen species. J Appl Physiol 111(4):980-988, 2011.

Paffett ML, Riddle MA, Resta TC, Walker BR. Altered membrane lipid domains limit pulmonary endothelial calcium entry following chronic hypoxia. Am J Physiol 301(4):H1331-H1340, 2011.

Snow JB, Gonzalez Bosc LV, Kanagy NL, Walker BR, Resta TC. Role for PKCß in enhanced endothelin-1-induced pulmonary vasoconstrictor reactivity following intermittent hypoxia. Am J Physiol 301(5):L745-L754, 2011.

Paffett ML,  Riddle MA, Kanagy NL, Resta TC, Walker BR.  Altered PKC regulation of pulmonary endothelial store- and receptor-operated Ca2+ entry following chronic hypoxia.  J Pharmacol Exp Ther. 334(3):753-760, 2010.

Resta TC , Broughton BR, Jernigan NL. Reactive oxygen species and RhoA signaling in vascular smooth muscle: role in chronic hypoxia-induced pulmonary hypertension.Adv Exp Med Biol. 661:355-373, 2010 [Invited Review]. 

Broughton RS, Jernigan NL, Norton CE, Walker BR, Resta TC.  Chronic hypoxia augments depolarization-induced Ca2+-sensitization in pulmonary vascular smooth muscle through superoxide-dependent stimulation of RhoA.  Am J Physiol. 298(2):L232-L242, 2010. 

Gonzalez Bosc LV, Resta T, Walker B, Kanagy NL.  Mechanisms of intermittent hypoxia-induced hypertension.  J Cell Mol Med. 14(1-2):3-17, 2010. [Invited Review]

Jernigan NL, Walker BR, Resta TC. Pulmonary endothelium and vasomotor control.  In: The Pulmonary Endothelium.  New York: Wiley, Inc., pp. 185-202, 2009.  

Snow, J.B., N.L. Kanagy, B.R. Walker, and TC Resta.  Rat strain differences in pulmonary vascular smooth muscle Ca2+ entry following chronic hypoxia.  Microcirculation. 16(7):603-614, 2009 . 

Jernigan, N.L., M.L. Paffett, B.R. Walker, and T.C. Resta.  ASIC1 contributes to pulmonary vascular smooth muscle store-operated Ca2+ entry.   Am J Physiol. 297(2):L271-L285, 2009. 

Haas, E., I. Bhattacharya, E. Brailoiu, M. Damjanovic, G.C. Brailoiu, L. Mueller-Guerre, N.A. Marjon, A. Gut, R. Minotti, M.R. Meyer, K. Amann, E. Ammann, A. Perez-Dominguez, M. Genoni, D.J. Clegg, N.J. Dun, T.C. Resta, E.R. Prossnitz, and M. Barton.  Regulatory role of G-protein coupled estrogen receptor for vascular function and obesity.   Circ Res . 104:288-291, 2009 . 

Jernigan, N.L., B.R. Walker, and T.C. Resta.  Reactive oxygen species mediate RhoA/Rho kinase-induced Ca2+ sensitization in pulmonary vascular smooth muscle following chronic hypoxia.  Am J Physiol Lung Cell Mol Physiol. 295:L515-L529, 2008. 

Broughton, B.R.S., B.R. Walker, and T.C. Resta.  Chronic hypoxia induces Rho kinase-dependent myogenic tone in small pulmonary arteries.   Am J Physiol Lung Cell Mol Physiol.  2 94(4):L787-L806, 2008. 

Gonzales, R.J., J.M. Bryant, J.S. Naik, T.C. Resta, and B.R. Walker.  Gender differences in mesenteric vasoconstrictor reactivity following chronic hypoxia. Microcirculation 2008 15(6):473-484, 2008. 

Snow, J.B., V. Kitzis, C.E. Norton, S.N. Torres, K.D. Johnson, N.L. Kanagy, B.R. Walker, and T.C. Resta.  Differential effects of chronic hypoxia and intermittent hypocapnic and eucapnic hypoxia on pulmonary vasoreactivity.  J. Appl. Physiol.  104:110-118, 2008 .