Paul G. McGuire, PhD

Paul McGuire

Associate Dean Undergraduate Medical Education

Research Interests  

Research in our laboratory is focused on various aspects of basic vascular cell biology and concentrates primarily on the molecular basis of angiogenesis and the regulation of vascular permeability seen in conditions such as diabetic retinopathy, retinopathy of prematurity and age-related macular degeneration.  These studies make use of histological, biochemical and genetic techniques in both animal models of retinal neovascularization and diabetes as well as in isolated vascular endothelial cells and pericytes.  Our primary area of emphasis focuses on the factors and mechanisms that regulate the permeability of the blood-retinal-barrier in response to diabetes.  We are investigating how the alteration of adherens and tight junction proteins by hyperglycemia and growth factors leads to alteration of endothelial monolayer function and subsequent retinal edema.  Additional studies are focused on the role of specific extracellular proteinases in ocular angiogenesis, including the serine proteinase urokinase and members of the matrix metalloproteinase family of enzymes. 

Education

1980, B.S., Biology, Colorado State University
1984, Ph.D., Anatomy, Colorado State University
1984-87; Research Fellow (Developmental Biology), Harvard Medical School
1987-89; Research Fellow (Biochemistry and Genetics), University of Colorado

Current Lab Personnel

Sampathkumar Rangasamy, Post Doctoral Fellow
Joann Maestes, HS Research Tech
Narayanasamy Angayarkanni, Visiting Scientist
Amber Messier, Clinical Fellow

Publications 

Majka, S.M., McGuire, P.G. and Das, A.  2002. Regulation of  Matrix Metalloproteinase Expression by Tumor Necrosis Factor in a Murine Model of Retinal Neovascularization.
 Investigative Ophthalmology and Visual Science. 43:260-266.

McGuire, P.G., Jones, T.R.,.Talarico, N., Warren, E. and Das, A. 2003.  The Urokinase/Urokinase Receptor System in Retinal Neovascularization: Inhibition by Å6 Suggests A New Therapeutic Target. 
Investigative Ophthalmology and Visual Science. 44-2736-2742.

Das, A., Fanslow, W., Cerretti, D., Warren, E., Talarico, N., and McGuire, P.G. 2003. Angiopoietin/Tek Interactions Regulate MMP-9 Expression and Retinal Neovascularization. Laboratory Investigation.83:1637-1645.

 Das, A. and McGuire P.G. 2003. Retinal and Choroidal Angiogenesis: Pathophysiology and Strategies for Inhibition. Prog Retin Eye Res. Nov;22(6):721-48.

 Das, A., Boyd, N., Jones, TR., Talarico, N., and McGuire, PG. 2004.  A Peptide Inhibitor of the Urokinase/Urokinase Receptor System Inhibits Choroidal Neovascularization in a Mouse Model.  Archives of Ophthalmology. 122:1844-1849.

Giebel, S.J., Menicucci,G., McGuire, P.G. and Das, A.2005. Matrix Metalloproteinases in Early Diabetic Retinopathy and Their Role in Alteration of the Blood-Retinal-Barrier. Laboratory Investigation. 85:597-607.

 Das, A., McGuire, PG. 2005. Role of Urokinase Inhibitors in Choroidal Neovascularization.  Seminars in Ophthalmology. 21: 23-27.

Das, A., McGuire, PG. 2006. Proteinases in Ocular Angiogenesis. In; Retinal and Choroidal Neovascularization. Ed. Penn, J., Kluwer/Springer Academic Publisher.

Colombo, ES., Menicucci, G.,  McGuire, P.G., and Das, A. 2007.  Hepatocyte Growth Factor/Scatter Factor Promotes Retinal Angiogenesis Through Increased Urokinase Expression. Investigative Ophthalmology and Visual Science. 48:1793-1800.

Navaratna, D., McGuire, P.G., Menicucci, G., and Das, A. 2007. Proteolytic Degradation of VE-Cadherin Alters the Blood-Retinal Barrier in Diabetes. Diabetes. 56: 2380-2387.

Navaratna, D., Maestas, J., McGuire, P.G., and Das, A. 2008. Retinal Neovascularization is Suppressed with an Antagonist to VE-cadherin.  Archive of Ophthalmology. 126(8): 1082-1088.

Navaratna, D., Menicucci, G., Maestas, J., Srinivasan, R., McGuire, P.G. and Das, A. 2008. A Peptide Inhibitor of the Urokinase/Urokinase Receptor System Inhibits Alteration of the Blood-Retinal-Barrier in Diabetes. FASEB Journal. 22:3310-3317.

Das, A and McGuire P.G. 2008. "Proteinases in Ocular Angiogenesis", in Retinal and Choroidal Neovascularization, ed. Penn, J. Kluwer/Springer Academic Publisher.

Das, A and McGuire P.G. 2008.  "Beyond VEGF:Other Factors Important in Retinal Neovascularization". in Diabetic Retinopathy, ed. Duh E, Humana Press.

Basu, A., Menicucci, G., Maestas, J., Das A., and McGuire P.G. 2009. Plasminogen Activator Inhibitor-1 (PAI-1) Facilitates Retinal Angiogenesis in a Model of Oxygen-Induced Retinopathy.  Investigative Ophthalmology and Visual Science. 50:4974-4981.