Oscar A. Bizzozero, PhD, Chairman

Research Interestsbizzozero

My laboratory is interested in understanding the molecular processes that underlie tissue damage in multiple sclerosis (MS), the most common demyelinating disease of the central nervous system (CNS) in humans. Currently, our efforts are devoted towards elucidating the mechanism(s) of oxidation (carbonylation) of CNS proteins using animal models of acute, relapsing/remitting and chronic MS, several cell culture systems and post-mortem brain specimens from MS patients. 

 

Education, Honors and Professional Experience

1979 – Medical Biochemist, University of Buenos Aires, Argentina

1983 – Ph.D. Biochemistry, University of Buenos Aires, Argentina

1984-1990 – Post-Doctoral Education; Dept. of Biochemistry, E.K. Shriver Center for Mental Retardation, Waltham, MA; Dept. of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA; Dept. of Neurology, Massachusetts General Hospital, Boston, MA

1983-present – Member of the International Soc. Neurochemistry

1985-present – Member of the American Soc. Neurochemistry

1998-2004 – Reviewer, NIH, Brain Disorders and Clinical Neurosciences (BDCN-4)

2005-2011 – Reviewer, NIH, Clinical Neuroimmunology and Brain Tumors (CNBT-1)

Awards

1984 - Sch. of Pharm. & Biochem. Award to the best doctoral thesis - Univ. Buenos Aires

1987- Jordi-Folch Memorial Award for outstanding contributions to neuroscience research - Am. Soc. Neurochemistry

1999 & 2001 - “Dean’s Award of Distinction” in recognition of outstanding faculty performance, Univ. New Mexico-HSC

2006 - “Earl Walker Neuroscience Award” in recognition of outstanding faculty performance, Univ. New Mexico-HSC

Selected Publications (from over 60)

Zheng, J. and Bizzozero, O.A. (2011) Decreased activity of the 20S proteasome in the brain white matter and gray matter of patients with multiple sclerosis. J. Neurochem. 117: 143-153.

Zheng, J. and Bizzozero, O.A. (2010) Reduced proteasomal activity contributes to the accumulation of carbonylated proteins in chronic experimental encephalopmyelitis. J. Neurochem. 115: 1556-1467.

Zheng, J. and Bizzozero, O.A. (2010) Accumulation of protein carbonyls within cerebellar astrocytes in murine experimental autoimmune encephalomyelitis. J. Neurosci. Res. 88: 3376-3385.

Bizzozero, O.A. and Zheng, J. (2009) Identification of major S-nitrosylated proteins in murine experimental autoimmune encephalomyelitis. J. Neurosci. Res. 87: 2881-2889.

Romero, J.M. and Bizzozero, O.A. (2009) Intracellular glutathione mediates the denitrosylation of protein nitrosothiols in the rat spinal cord. J. Neurosci. Res. 87: 701-709.

Smerjac, S. and Bizzozero, O.A. (2008) Cytoskeletal protein carbonylation and degradation in experimental autoimmune encephalomyelitis. J. Neurochem 105: 763-772.

Romero J.M. and Bizzozero O.A. (2006). Extracellular S-nitrosoglutathione, but not S-nitrosocysteine or N2O3, mediates protein S-nitrosation in rat spinal cord slices. J. Neurochem. 99: 1299-1310.

Bizzozero, O.A., Ziegler, J.L., DeJesus, G. and Bolognani, F. (2006) Acute depletion of reduced glutathione causes extensive carbonylation of rat brain proteins. J. Neurosci. Res. 83: 656-667.

Bizzozero, O.A., DeJesus, G., Callahan K. and Pastuszyn, A. (2005) Elevated protein carbonylation in the brain white matter and gray matter of patients with multiple sclerosis. J. Neurosci. Res. 81: 687-695.

Bizzozero, O.A., Malkoski, S.P., Mobarak, C., Bixler, H.A. and Evans, J. (2002) Mass-spectrometric analysis of myelin proteolipids reveals new features of this family of palmitoylated membrame proteins. J. Neurochem. 81: 636-645.

Bizzozero, O.A., Bixler, H.A., and Pastuszyn, A. (2001) Structural determinants influencing the reaction of cysteine-containing peptides with palmitoyl-CoA and other thioesters. Biochem. Biophys. Acta 1545: 278-288.

Bizzozero, O.A., Bixler, H.A, Davis, J., Espinosa, A. and Messier, A.M. (2001) Chemical deacylation reduces the adhesive properties of proteolipid protein and leads to decompaction of the myelin sheath. J. Neurochem. 76: 1129-1141.

Sanchez, P., Tetzloff, S.U. and Bizzozero, O.A. (1998) Veratridine-induced depolarization reduces the palmitoylation of brain and myelin glycerolipids. J. Neurochem. 70, 1448-1457.

Tetzloff, S.U. and Bizzozero, O.A. (1998) Palmitoylation of proteolipid protein from rat brain myelin using endogenously-generated 18O-fatty acids. J. Biol. Chem. 273:279-285.

Bharadwaj, M. and Bizzozero, O.A. (1995) Myelin P0 Glycoprotein and a synthetic peptide containing the palmitoylation site are both autoacylated. J. Neurochem. 65:1805-1815.

Bizzozero, O.A., Fridal, K. and Pastuszyn, A. (1994) Identification of the palmitoylation site in rat myelin PO glycoprotein. J. Neurochem. 62:1163-1171.

Bizzozero, O.A., Leyba, J., and Nunez, D.J. (1992) Characterization of proteolipid protein fatty acylesterase from rat brain myelin. J. Biol. Chem. 267:7888-7894.

Bizzozero, O.A. and Good, L. (1991) Rapid metabolism of fatty acids covalently bound to myelin proteolipid protein. J. Biol. Chem. 266:17092-17098

Bizzozero, O.A., Zuniga, G. and Lees, M.B. (1991) Fatty acid composition of human myelin proteolipid protein in peroxisomal disorders. J. Neurochem. 56:872-878..

 Bizzozero, O.A., McGarry, J.F. and Lees, M.B. (1987) Autoacylation of myelin proteolipid protein with acyl-coenzyme A. J. Biol. Chem. 262:13550-13557